Most of the fanbase is most familiar with the Pokemon anime’s interpretation of Mewtwo’s story. The 150th Pokemon was the antagonist in the very first Pokemon Movie, Mewtwo Strikes Back. At the beginning of the Movie, we see Mewtwo gaining consciousnesses behind a glass tube. Dr. Fuji, the head scientist of the cloning project responsible for Mewtwo’s creation, explains to the Pokemon that it is a cloned specimen of a long extinct Mew. Quickly putting two and two together, Mewtwo realizes that it is no more than an experiment to its creators and destroys the lab, including everything and everyone in it.